HemoCue WBC DIFF System
The HemoCue WBC DIFF System measures white blood cell (WBC) count including a five-part differential at the point of care in order to rapidly provide information about the state of the immune system to medical professionals.
No similar devices are known, however, another method to gain immune cell counts is to use a microscope and cell stains to identify and count cells
Lindberg, Stellan, and Johnny Svensson. 2009. Enumeration of white blood cells. USPTO 7521243. US Patent, filed April 11, 2005, and issued April 21, 2009.
The manufacturer specifies a detection range of 300-30000 cells/µL, with a sample volume of 10uL, and a measurement time of less than 5 minutes. Source: WBC Diff Product Sheet
In the independent study by Hammersmith Hospital, the device provided reliable comparability in the range of 0.4–30.0 × 109/l. This is slightly narrower than the range of 0.3–35 × 109/l specified by the manufacturer; however, samples with WBC < 0.4 × 109/l were flagged as low (code LLL) and conversely, those with counts above 30.0 × 109/l were flagged as high (code HHH); thus, in a clinical setting, this flagging would provide adequately reliable information.
Unreliably measuring immune function could provide incorrect information to doctors, leading to incorrect diagnosis and treatment.
Osei-Bimpong, A., Jury, C., McLean, R., Lewis, S.M. “Point-of-care method for total white cell count: an evaluation of the HemoCue WBC device.” Int. J. Lab Hematol, 31:6 (2009)
Casey, Janet R., and Michael E. Pichichero. 2009. “A Comparison of 2 White Blood Cell Count Devices to Aid Judicious Antibiotic Prescribing.” Clinical Pediatrics 48 (3): 291–94.
Russcher, H., N. Van Deursen, and R. de Jonge. 2013. “Evaluation of the HemoCue WBC DIFF System for Point-of-Care Counting of Total and Differential White Cells in Pediatric Samples.” Ned Tijdschr Klin Chem.
Lindberg, Stellan, Inger Jönsson, Magnus Nilsson, Elin Johnsson, and Tomas Jonasson-Bjäräng. 2014. “A Novel Technology for 5-Part Differentiation of Leukocytes Point-of-Care.” Point of Care 13 (2).
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