The PATH disposable-syringe jet injector (DSJI) is a sterile needle-free device that uses a single-dose syringe and a pressurized liquid stream rather than a needle to penetrate through the skin and deliver injections to the intradermal, subcutaneous, or intramuscular tissues. The PATH DSJI aims to reduce needle reuse and the associated disease spread due to shortages of sterile needles and trained lab workers. An estimated 23.5 million new HIV, hepatitis B, and hepatitis C infections occur every year through needle reuse and accidental needle stick injuries.
A pressurized liquid stream containing the vaccine/medicine directly enters the skin tissue without using a needle to pierce the skin. This direct injection delivers medicine and ensures that no contamination is observed. DSJIs require no change in vaccine formulation and can be filled from multi-dose and single-dose vials at the point of use.
Intellectural Property Type
User Provision Model
This product is distributed by humanitarian organizations like WHO to health care professionals and centers.
Distributions to Date Status
PATH is conducting user assessments of device prototypes based on user feedback and has supported clinical research activities.
The depth of delivery can be made to vary from intradermal (the 2-mm thick upper layer of the skin) all the way to intramuscular depths
Maximum injection volume (mL)
Provided by the manufacturer
There are no replaceable components other than the vaccine/medicine vials.
Manufacturer Specified Performance Parameters
Vetted Performance Status
Testing performed by the manufacturer, however, no third-party testing has been completed.
No known safety hazards are related to this product.
Complementary Technical Systems
A reliable medical/health care is essential to use this product.
Academic Research and References
Weston, T. E. (1996). U.S. Patent No. 5,480,381. Washington, DC: U.S. Patent and Trademark Office.
Alchas, P. G., & Prais, A. W. (1994). U.S. Patent No. 5,334,144. Washington, DC: U.S. Patent and Trademark Office.
Singh, I., & Morris, A. P. (2011). Performance of transdermal therapeutic systems: Effects of biological factors. International journal of pharmaceutical investigation, 1(1), 4.
Compliance with regulations
The product is approved by WHO standards.
Disposable-syringe jet injector technology has the potential to provide safer and more affordable vaccines to millions of people around the world as claimed by WHO.