Updated on December 19, 2023


Created on October 21, 2021


Upcoming Update

PremieBreathe is a breathing aid to help premature newborns in resource-constrained settings.

Developed By
  1. PremieBreathe
Content Partners


Product Description

PremieBreathe is a low-cost breathing aid for newborn babies that provides humidified air flow to neonates and was developed by a start-up formed by a multi-departmental collaboration at Yale University. The product is designed for settings that lack safe respiratory devices and is intended to address neonatal mortality due to respiratory complications. In 2016 PremieBreathe was under trial. We have no further updated information as of 2021.

Target SDGs

SDG 3: Good Health and Well-Being

Market Suggested Retail Price


Target Users (Target Impact Group)

Small and Medium-sized Enterprises, Public Sector Agencies

Distributors / Implementing Organizations


Competitive Landscape

Manufacturing/Building Method

This product is currently in the prototyping phase and not yet manufactured at scale. Prototypes are being developed at Yale University in Prof. Gonzalez's lab. 

Intellectural Property Type

Select Type

User Provision Model

The designers have not yet selected their user provision model.

Distributions to Date Status

None - product still in prototype stage

Design Specifications

PremieBreathe, is a humidified high flow nasal cannula (HHFNC) device that delivers variable flows of warmed, humidified, and oxygenated air to provide respiratory support for premature and newborn infants.  The device incorporates an ultraviolet water sterilization mechanism to kill waterborne bacteria. It also incorporates reusable, biofouling-­resistant tubing rather than the disposable circuit used in the commercial technology, embodied by a mobile, compact housing, designed to incorporate a rechargeable battery source, ensures that our device can provide portable oxygen therapy for critically ill newborns in need of undisrupted support, while in transport between hospitals and health centers.

Product Schematics

Technical Support

Provided by the manufacturers

Replacement Components

Replacement components include flow regulators and humidification bottles.



Manufacturer Specified Performance Parameters

The maufacturers set out to develop a low-cost respirator that can safely provide warmed, humidified and blended oxygen to neonates in need.

Vetted Performance Status

Pilot tests were performed in Ethiopia at Ayder Referral Hospital to establish the performance and functional parameters after about a half-a-dozen prototyping iterations.


The manufacturers have taken steps to test the device in a clinical environment to ensure its safety.

Complementary Technical Systems


Academic Research and References

Wang, D., 2016, “PremieBreathe: A Low-Cost Respiratory Aid for the Developing World.

Matthews, M., et al., 2017, “PREferred Providers,” ASEE Prism, 27(2), pp. 24-31.

2018, “Third WHO global forum on medical devices: international conference center Geneva: Geneva, Switzerland 10–12 May 2017,”  No. WHO/EMP/2018.02,World Health Organization.

Compliance with regulations


Other Information


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